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Unlock Cardboard Characters & Streets Level:
Beat the game on easy to unlock Cardboard Characters & Streets Level in arcade mode.

Unlock Rotating heads:
Get Silver on the Pane in the Neck challenge.

Unlock Hector Babasco and Lean Molly:
Get Gold on Adios Amigos.

Unlock Sewer Zombie:
Get Gold on Behead the Dead.

Unlock funny hats:
Get a silver or gold medal on the following levels to unlock slilly hats.

Level - Hat:
2280 Escape from Neotokyo - Big Ears
1853 Silent But Deadly - Viking
2019 Trouble At The Docks - Pirate

Unlock story mode characters:
Complete the level on medium difficulty to unlock the bonus character.

Level - Character:
Return to Planet X - Ozor Mox
Wild West - The Colonel
NeoTokyo - Sadako
Aztec Ruins - Stone Golem
Atom Smasher - Khallos
Space Station - Reaper Splitter
Siberia - Hybrid Mutant
Chicago - Big Tony
Notre Dame - Jacque de la Morte
Robot Factory - Machinist

Destroying The Bio-Hazard Case
When you restore the power in the building, go down to the "Digging Site". When you get there, you will see a case with something in it. Make sure you have plenty of Timed Mines. Walk towards it and throw four or five Timed Mines at it then run away. When it blows up, the woman on the speaker will start talking. People with very good guns (Flame Thrower, Shotgun, Machine Guns, etc.) will appear. You will also have a new objective to not let any mutants survive.

Faster Reload
Instead of reloading normally, go to the next weapon, then back to the previous weapon. This reloads weapons that reload very slowly.